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Facteurs déterminant la fréquence et la sévérité de la mucosite buccale chez les patients subissant une autogreffe de cellules souches
Abstract
Cette étude descriptive rétrospective portait sur la fréquence de la mucosite buccale et examinait l’incidence de certaines variables sur le développement de la mucosite buccale chez les patients subissant une autogreffe de cellules souches. La mucosite buccale est apparue chez 90 % des patients, tandis que 53,57 % ont souffert d’ulcérations. En moyenne, la mucosite buccale apparaissait le 7e jour, perdurait 6 jours et se résorbait le 13e jour suivant le début de la chimiothérapie. Des bains de bouche au bicarbonate de soude et des collutoires pour la mucosite constituaient les interventions les plus souvent pratiquées; 72,92 % de ces interventions étaient utilisées à titre de prévention secondaire. La mucosite buccale entretenait un rapport significatif avec le diagnostic (lymphome), la chimiothérapie (étoposide en association avec melphalan) et le niveau de prévention (secondaire). Le diagnostic (lymphome), la chimiothérapie (étoposide en association avec melphalan), la concentration sérique de créatinine (pic) et le niveau de prévention (secondaire) constituaient des variables prédictives indépendantes de la mucosite buccale.
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Balducci, L., & Mowry, K. (1992). Pharmacology and organ toxicity of
chemotherapy in older patients. Oncology, 6, 62-68.
Beck, S. (1979). Impact of a systematic oral care protocol on stomatitis
after chemotherapy. Cancer Nursing, 2, 185-199.
Berger, A., & Eilers, J. (1998). Factors influencing oral cavity status
during high-dose antineoplastic therapy: A second data analysis.
Oncology Nursing Forum, 25, 1623-1626.
Borowski, B., Benhamou, E., Pico, J.L., Laplanche, A., Margainaud, J.P.,
& Hayat, M. (1994). Prevention of oral mucositis in patients treated
with high-dose chemotherapy and bone marrow transplantation: A
randomized controlled trial comparing two protocols of dental care.
Oral Oncology, European Journal of Cancer, 30B, 93-97.
Dodd, M.J., Dibble, S.L., Miaskowski, C., MacPhail, L., Greenspan, D.,
Paul, S.M., et al. (2000). Randomized clinical trial of the effectiveness
of three commonly used mouthwashes to treat chemotherapy-induced
mucositis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod,
(1), 39-47.
Katano, M., Nakamura, M., Matsuo, T., Iyama, A., & Hisatsugu, T. (1995).
Effect of granulocyte colony stimulating factor (G-CSF) on
chemotherapy-induced oral mucositis. Surgery Today, 25, 202-206.
Larson, P.J., Miaskowski, C., MacPhail, L., Dodd, M.J., Greenspan, D.,
Dibble, S.L., et al. (1998). The pro-self mouth aware program: An
effective approach for reducing chemotherapy-induced mucositis.
Cancer Nursing, 21(4). 263-268.
Lieschke, G., Ramenghi, U., O’Connor, M., Sheridan, W., Szer, J.,
Morstyn, G. (1992). Studies of oral neutrophil levels in patients
receiving G-CSF after autologous marrow transplantation. British
Journal of Haematology, 82, 589-95.
McCarthy, G.M., Awde, J.D., Ghandi, H., Vincent, M., & Kocha, W.I.
(1998). Risk factors associated with mucositis in cancer patients
receiving 5-fluorouracil. Oral Oncology, 34, 484-490.
National Cancer Institute. (2002). Oral complications of chemotherapy
and head/neck radiation (PDQ). Retrieved October 30, 2003, from
http://www.cancer.gov/cancerinfo/pdq/supportivecare/oral
complications/HealthProfessional
Neuman, B. (1995). The Neuman systems model (3rd ed.). Norwalk,
CT: Appleton & Lange.
Raber-Durlacher, J.E., Weijl, N.I., Abu Saris, M., de Koning, B.,
Zwinderman, A.H., & Osanto, S. (2000). Oral mucositis in patients
treated with chemotherapy for solid tumours: A retrospective analysis
of 150 cases. Supportive Care in Cancer, 8, 366-371.
Rapoport, A.P., Miller Watelet, L.F., Linder, T., Eberly, S., Raubertas,
R.F., Lipp, J., et al. (1999). Analysis of factors that correlate with
mucositis in recipients of autologous and allogenic stem cell
transplants. Journal of Clinical Oncology, 17, 2446-2453.
Sonis, S.T. (1993). Oral complications of cancer therapy. In V.T. De Vita,
S. Hellman, & S.A. Rosenberg (Eds.), Cancer: Principles and
practices of oncology (4th ed.) (p. 2385-2394). Philadelphia, PA:
Lippincott.
Stricker, C.T., & Sullivan, J. (2003). Evidence-based oncology oral care
clinical practice guidelines: Development, implementation, and
evaluation. Clinical Journal of Oncology Nursing, 7(2), 222-227.
Woo, S., Sonis, S.T., Monopoli, M.M., & Sonis, A.L. (1993). A
longitudinal study of oral ulcerative mucositis in bone marrow
transplant recipients. Cancer, 72, 1612-1617.
World Health Organization. (1979). Handbook for reporting results of
cancer treatment. Geneva, Switzerland: WHO.
Yeager, K.A., Webster, J., Cram, M., Kasow, J., & McGuire, D.B. (2000).
Implementation of an oral care standard for leukemia and
transplantation patients. Cancer Nursing, 23, 40-47.
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