Prise de position de l’ACIO : Les soins infirmiers en oncologie basés sur la génomique
Abstract
Le personnel infirmier en oncologie apporte une contribution essentielle à la prestation et à la continuité des soins de haute qualité contre le cancer, fondés sur des données probantes. Au Canada et dans d’autres pays, les technologies basées sur la génomique sont largement intégrées aux services d’oncologie (Konstantinopoulos et al., 2020; Liu et al., 2022). Les résultats des tests génomiques sont utilisés pour accroître la précision du diagnostic, sélectionner des thérapies ciblées et réduire le fardeau des traitements contre le cancer (Konda et al., 2023; Weymann et al., 2021). Les résultats des tests aident également à prédire les risques de cancer et d’autres maladies, et à identifier les personnes ayant une prédisposition héréditaire au cancer, qui pourraient bénéficier de mesures de prévention et de réduction des risques (Garutti et al., 2023). Cependant, les personnes au Canada ne peuvent profiter de ces avantages que si elles ont un accès opportun, approprié et équitable à des informations génomiques précises, à des tests et à un suivi adapté.
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Bokkers, K., Vlaming, M., Engelhardt, E. G., Zweemer, R. P., van Oort, I. M., Kiemeney, L. A. L. M., Bleiker, E. M. A., & Ausems, M. G. E. M. (2022). The feasibility of implementing mainstream germline genetic testing in routine cancer care - A systematic review. Cancers, 14(4), 1059. https://doi.org/10.3390/cancers14041059
Canadian Association of Nurses in Oncology/ Association canadienne des infirmières en oncologie. (2024). Cancer care pocket guide. https://cdn.ymaws.com/www.cano- acio.ca/resource/resmgr/files/ccpg_en_2024.pdf
Canadian Partnership Against Cancer. (2020). Lung cancer and equity: A focus on income and geography. https://s22457.pcdn.co/wp-content/uploads/2020/11/Lung-cancer-and-equity- report-EN.pdf
Chiu, P., Gretchev, A., Limoges, J., Puddester, R., Carlsson, L., Pike, A., Leslie, K., Dordunoo, D. (2024a). Fostering pan-Canadian collaboration to advance new nursing practice: A case study from the genomics experience. Canadian Journal of Nursing Leadership, 37(2), 41–48. https://doi.org/10.12927/cjnl.2024.27470
Chiu, P., Limoges, L., Pike, A., Calzone, K., Tonkin, E., Puddester, R., Gretchev, A., Dewell, S, Newton, L., & Leslie, K. (2024b). Integrating genomics into Canadian oncology nursing policy: Insights from a comparative policy analysis. Journal of Advanced Nursing, 80, 4488–4509. https://onlinelibrary.wiley.com/doi/epdf/10.1111/jan.16099
Chiu, P., Limoges, J., Puddester, R., Gretchev, A., Carlsson, L., Leslie, K., Flaming, D., Meyer, A., & Pike, A. (2024c). Developing policy infrastructure to guide genomics-informed oncology nursing in Canada: An interpretive descriptive study. Canadian Journal of Nursing Research, 56(4), 363–376. https://doi.org/10.1177/08445621241252615
Diez de Los Rios de la Serna, C., Fernández-Ortega, P., & Lluch-Canut, T. (2022). Educational programme for cancer nurses in genetics, health behaviors and cancer prevention: A multidisciplinary consensus study. Journal of Personalized Medicine, 12(7), 1104. https://doi.org/10.3390/jpm12071104
Diez de Los Rios de la Serna, C., Lluch-Canut, M. T., & Fernández-Ortega, M. P. (2024). Hereditary cancer syndrome carriers: Feeling left in the corner. Seminars in Oncology Nursing, 40(3), 1–9. https://doi.org/10.1016/j.soncn.2024.151624
Dowling, M., Pape, E., Geese, F., Van Hecke, A., Bryant-Lukosius, D., Cerón, M. C., Fernández-Ortega, P., Marquez-Doren, F., Ward, A., Semple, C., King, T., Glarcher, M., & Drury, A. (2024). Advanced practice nursing titles and roles in cancer care: A scoping review. Seminars in Oncology Nursing, 40(3), 1–10. https://doi.org/10.1016/j.soncn.2024.151627
Dragojlovic, N., Borle, K., Kopac, N., Nisselle, A., Nuk, J., Jevon, M., Friedman, J. M., Elliott, A. M., & Lynd, L. D. (2023). Workforce implications of increased referrals to hereditary cancer services in Canada: A scenario-based analysis. Current Oncology, 30(8), 7241–7251. https://doi.org/10.3390/curroncol30080525
Garutti, M., Foffano, L., Mazzeo, R., Michelotti, A., Da Ros, L., Viel, A., Miolo, G., Zambelli, A., & Puglisi, F., (2023). Hereditary cancer syndromes: A comprehensive review with a visual tool. Genes, 14, 1–27. https://doi.org/10.3390/genes14051025
Hamilton, J. G., Symecko, H., Spielman, K., Breen, K., Mueller, R., Catchings, A., Trottier, M., Salo-Mullen, E. E., Shah, I., Arutyunova, A., Batson, M., Gebert, R., Pundock, S., Schofield, E., Offit, K., Stadler, Z. K., Cadoo, K., Carlo, M. I., Narayan, V., … Domchek, S. M. (2021). Uptake and acceptability of a mainstreaming model of hereditary cancer multigene panel testing among patients with ovarian, pancreatic, and prostate cancer. Genetics in Medicine, 23(11), 2105–2113. https://doi.org/10.1038/s41436-021-01262-2
Konda, P., Garinet, S., Van Allen, E. M., & Viswanathan, S. R. (2023). Genome-guided discovery of cancer therapeutic targets. Cell Reports, 42(8), 1–18. https://doi.org/10.1016/j.celrep.2023.112978
Konstantinopoulos, P. A., Norquist, B., Lacchetti, C., Armstrong, D., Grisham, R. N., Goodfellow, P. J., Kohn, E. C., Levine, D. A., Liu, J. F., Lu, K. H., Sparacio, D., & Annunziata, C. M. (2020). Germline and somatic tumour testing in epithelial ovarian cancer: ASCO guideline. Journal of Clinical Oncology, 38(11), 1222–1245. https://doi.org/10.1200/JCO.19.02960
Limoges, J., Chiu, P., Dordunoo, D., Puddester, R., Pike, A., Wonsiak, T., Zakher, B., Carlsson, L., & Mussell, J. (2024a). Nursing strategies to address health disparities in genomics- informed care: A scoping review. JBI Evidence Synthesis, 22(11), 2267–2313. https://doi.org/10.11124/JBIES-24- 00009
Limoges, J., Puddester, R., Pike, A., Calzone, K., Carlsson, L., Letourneau, N., & Gretchev, A. (2024b). Leadership strategies for genomics integration: A descriptive study using the GGNPS-CA. Canadian Journal of Nursing Leadership, 37(2), 22–40. https://doi.org/10.12927/cjnl.2024.27467
Limoges, J., Puddester, R., Gretchev, A., Chiu, P., Calzone, K., Leslie, K., Pike, A., & Letourneau, N. (2025). Building a genomics-informed nursing workforce: Recommendations for oncology nursing practice and beyond. Current Oncology, 32(1), 14. https://doi.org/10.3390/curroncol32010014
Liu, G., Cheung, W. Y., Feilotter, H., Manthorne, J., Stockley, T., Yeung, M., & Renouf, D. J. (2022). Precision oncology in Canada: Converting vision to reality with lessons from international programs. Current Oncology, 29(10), 7257–7271. https://doi.org/10.3390/curroncol29100572
Loughrey, M., O’Connell, L. V., McSorley, L., Martin, S., Hanly, A., Winter, D. C., Frayling, I. M., Sheahan, K., & Kennelly, R. (2024). Mainstreaming cancer genetics: Feasibility of an advanced nurse practitioner-led service diagnosing Lynch syndrome from colorectal cancer in Ireland. Familial Cancer, 24(1), 2. https://doi.org/10.1007/s10689-024-00427-7
Maghfiroh, H., Zubaidah, S., Mahanal, S., & Susanto, H. (2023). Definition and conceptual model of genetics literacy: A systematic literature review. International Journal of Public Health Science, 12, 554. https://doi.org/10.11591/ijphs.v12i2.22679
Mahon, S. (2022). Oncology nurse practitioners in genetics: Examining scope of practice and competence. Clinical Journal of Oncology Nursing, 26(2), 141–145. https://doi.org/10.1188/22.CJON.141-145
Monje-Garcia, L., Bill, T., Farthing, L., Hill, N., Kipps, E., Brady, A. F., Kemp, Z., Snape, K., Myers, A., Abulafi, M., & Monahan, K. (2023). From diagnosis of colorectal cancer to diagnosis of Lynch syndrome: The RM Partners quality improvement project. Colorectal Disease, 25(9), 1844–1851. https://doi.org/10.1111/codi.16707
National Health Service. (2023). Genomics. https://www.england.nhs.uk/long-read/genomics/
National Human Genome Research Institute. (2025a). Genetics. In the Talking glossary of genomic and genetic terms. https://www.genome.gov/genetics-glossary/Genetics
National Human Genome Research Institute. (2025b). Genomics. In the Talking glossary of genomic and genetic terms. https://www.genome.gov/genetics-glossary/genomics
Oncology Nursing Society. (2025). Variant subcategories. In the Genomics taxonomy. https://www.ons.org/variant-subcategories
O’Shea, R., Crook, A., Jacobs, C., Kentwell, M., Gleeson, M., Tucker, K. M., Hampel, H., Rahm, A. K., Taylor, N., Lewis, S., & Rankin, N. M. (2023). A mainstreaming oncogenomics model: Improving the identification of Lynch syndrome. Frontiers in Oncology, 13, 1–10. https://doi.org/10.3389/fonc.2023.1140135
Puddester, R., Limoges, J., Dewell, S., Maddigan, J., Carlsson, L., & Pike, A. (2023). The Canadian landscape of genetics and genomics in nursing: A policy document analysis. Canadian Journal of Nursing Research, 55(4),494–509. https://doi.org/10.1177/08445621231159164
Sick Kids. (2022). Genetic counselling. https://www.sickkids.ca/en/care-services/support- services/genetic-counselling/
Tindale, L. C., Zhantuyakova, A., Lam, S., Woo, M., Kwon, J. S., Hanley, G. E., Knoppers, B., Schrader, K. A., Peacock, S. J., Talhouk, A., Dummer, T., Metcalfe, K., Pashayan, N., Foulkes, W. D., Manchanda, R., Huntsman, D., Stuart, G., Simard, J., & Dawson, L. (2022). Gynecologic cancer risk and genetics: Informing an ideal model of gynecologic cancer prevention. Current Oncology, 29(7), 4632–4646. https://doi.org/10.3390/curroncol29070368
Weymann, D., Pollard, S., Chan, B., Titmuss, E., Bohm, A., Laskin, J., Jones, S. J. M., Pleasance, E., Nelson, J., Fok, A., Lim, H., Karsan, A., Renouf, D. J., Schrader, K. A., Sun, S., Yip, S., Schaeffer, D. F., Marra, M. A., & Regier, D. A. (2021). Clinical and cost outcomes following genomics-informed treatment for advanced cancers. Cancer Medicine, 10(15), 5131–5140. https://doi.org/10.1002/cam4.4076
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