Mesure de l’efficacité d’une intervention de massothérapie (par effleurage et pétrissage) sur l’intensité de la neuropathie périphérique induite par la chimiothérapie : essai clinique pilote randomisé

Rupinder Kaur, Reena Jairus, Meena Sudan

Abstract


Contexte : La neuropathie périphérique induite par la chimiothérapie est un effet secondaire du traitement qui dépend de la dose reçue et qui endommage les nerfs; les taux de prévalence rapportés sont de 68,1 % après 1 mois de traitement, de 60,0 % après 3 mois et de 30,0 % après 6 mois.

But de l’étude : Déterminer l’efficacité d’une intervention de massothérapie (par effleurage et pétrissage) sur l’intensité de la neuropathie périphérique chez les patients recevant de la chimiothérapie à base de platine.

Méthodologie : Soixante (60) patients qui en étaient à leur troisième ou quatrième cycle de chimiothérapie à base de platine ont été assignés de façon aléatoire à l’un des deux groupes selon un devis de type pré-test/post-test. Pendant un mois, le groupe expérimental a reçu des massages par effleurage et pétrissage avant les séances de chimiothérapie. La comparaison entre les niveaux d’intensité de la neuropathie périphérique a été effectuée à l’aide de la sous-échelle FACT/GOG-Ntx pour Functional Assessment of Cancer Therapy/Gynecologic Oncology Group – Neurotoxicity subscale (échelle d’évaluation fonctionnelle du traitement du cancer/groupe d’oncologie gynécologique – sous-échelle de neurotoxicité) après 7 jours, 14 jours, 21 jours et 28 jours,

Résultats : Avant l’intervention, le score moyen (+ÉT) d’intensité de la neuropathie périphérique induite par la chimiothérapie était de 17,17 (+4,907) dans le groupe expérimental et de 17,10 (+4,421) dans le groupe témoin (t = 0,055, p = 0,956). Les scores moyens post-test (+ÉT) après 28 jours étaient de 10,70 (±2,855) dans le groupe expérimental et de 16,27 (±3,039) dans le groupe témoin (p = 0,000). 

Conclusion : Les résultats du présent essai clinique pilote confirment l’efficacité de l’intervention (massage par effleurage et pétrissage) pour réduire l’intensité de la neuropathie périphérique induite par la chimiothérapie à base de platine.

Mots-clés : effleurage, pétrissage, neuropathie, périphérique, induite, chimiothérapie


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References


Addington, J., & Freimer, M. (2016). Chemotherapy-induced peripheral neuropathy: An update on the current understanding. F1000Research, 5(6), 1466. https://doi.org/10.12688/f1000research.8053.1

Andersen Hammond, E., Pitz, M., Steinfeld, K., Lambert, P., & Shay, B. (2020). An exploratory randomized trial of physical therapy for the treatment of chemotherapy-induced peripheral neuropathy. Neurorehabilitation and Neural Repair, 34(3), 235–246. https://doi.org/10.1177/1545968319899918

Bridges, D., Thompson, S. W. N., & Rice, A. S. C. (2001). Mechanisms of neuropathic pain. BJA: British Journal of Anaesthesia, 87(1), 12–26. https://doi.org/10.1093/bja/87.1.12

Calhoun, E. A., Welshman, E., Chang, C. H., Lurain, J. R., Fishman, D. A., Hunt, T. L., et al. (2003). Psychometric evaluation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group—Neurotoxicity (Fact/GOG-Ntx) questionnaire for patients receiving systemic chemotherapy. International Journal of Gynecological Cancer: Official Journal of the International Gynecological Cancer Society, 13, 741–748.

Cunningham, J. E., Kelechi, T., Sterba, K., Barthelemy, N., Falkowski, P., & Chin, S. H. (2011). Case report of a patient with chemotherapy-induced peripheral neuropathy treated with manual therapy (massage). Supportive Care in Cancer, 19(9), 1473–1476. https://doi.org/10.1007/s00520-011-1231-8

Duregon, F., Vendramin, B., Bullo, V., Gobbo, S., Cugusi, L., Di Blasio, A., Neunhaeuserer, D., Zaccaria, M., Bergamin, M., & Ermolao, A. (2018). Effects of exercise on cancer patients suffering chemotherapy-induced peripheral neuropathy undergoing treatment: A systematic review. Critical Reviews in Oncology/Hematology, 121, 90–100. https://doi.org/10.1016/j.critrevonc.2017.11.002

Dworkin, R. H., O’Connor, A. B., Backonja, M., Farrar, J. T., Finnerup, N. B., Jensen, T. S., Kalso, E. A., Loeser, J. D., Miaskowski, C., Nurmikko, T. J., Portenoy, R. K., Rice, A. S. C., Stacey, B. R., Treede, R.-D., Turk, D. C., & Wallace, M. S. (2007). Pharmacologic management of neuropathic pain: Evidence-based recommendations. Pain, 132(3), 237–251. https://doi.org/10.1016/j.pain.2007.08.033

Ewertz, M., Qvortrup, C., & Eckhoff, L. (2015). Chemotherapy-induced peripheral neuropathy in patients treated with taxanes and platinum derivatives. Acta Oncologica (Stockholm, Sweden), 54(5), 587–591. https://doi.org/10.3109/0284186X.2014.995775

Falkensteiner, M., Mantovan, F., Müller, I., & Them, C. (2011). The use of massage therapy for reducing pain, anxiety, and depression in oncological palliative care patients: A narrative review of the literature. ISRN Nursing, 2011, 1–8. https://doi.org/10.5402/2011/929868

Hartmann, J. T., & Lipp, H.-P. (2003). Toxicity of platinum compounds. Expert Opinion on Pharmacotherapy, 4(6), 889–901. https://doi.org/10.1517/14656566.4.6.889

Homesley, H. D., Filiaci, V. L., Markman, M., Bitterman, P., Eaton, L., Kilgore, L. C., Monk, B. J., & Ueland, F. R. (2007). Phase III trial of Ifosfamide with or without Paclitaxel in advanced uterine carcinosarcoma: A gynecologic oncology group study. Journal of Clinical Oncology, 25(5), 526–531. https://doi.org/10.1200/jco.2006.06.4907

Housley, S. N., Nardelli, P., Carrasco, D. I., Rotterman, T. M., Pfahl, E., Matyunina, L. V., McDonald, J. F., & Cope, T. C. (2020). Cancer exacerbates chemotherapy-induced sensory neuropathy. Cancer Research, 80(13), 2940–2955. https://doi.org/10.1158/0008-5472.can-19-2331

Kaley, T. J., & DeAngelis, L. M. (2009). Therapy of chemotherapy-induced peripheral neuropathy. British Journal of Haematology, 145(1), 3–14. https://doi.org/10.1111/j.1365-2141.2008.07558.x

Katta, B., Vijayakumar, C., Dutta, S., Biswajit Dubashi, & Prasad, V. (2023). The incidence and severity of patient-reported side effects of chemotherapy in routine clinical care: A prospective observational study. Cureus, 15(4). https://doi.org/10.7759/cureus.38301

Kleckner, I. R., Kamen, C., Gewandter, J. S., Mohile, N. A., Heckler, C. E., Culakova, E., Fung, C., Janelsins, M. C., Asare, M., Lin, P.-J., Reddy, P. S., Giguere, J., Berenberg, J., Kesler, S. R., & Mustian, K. M. (2017). Effects of exercise during chemotherapy on chemotherapy-induced peripheral neuropathy: A multicenter, randomized controlled trial. Supportive Care in Cancer, 26(4), 1019–1028. https://doi.org/10.1007/s00520-017-4013-0

McDonald, E. S., & Windebank, A. J. (2002). Cisplatin-induced apoptosis of DRG neurons involves bax redistribution and cytochrome c release, but not fas receptor signaling. Neurobiology of Disease, 9(2), 220–233. https://doi.org/10.1006/nbdi.2001.0468

Miltenburg, N. C., & Boogerd, W. (2014). Chemotherapy-induced neuropathy: A comprehensive survey. Cancer Treatment Reviews, 40(7), 872–882. https://doi.org/10.1016/j.ctrv.2014.04.004

Mols, F., van de Poll-Franse, L. V., Vreugdenhil, G., Beijers, A. J., Kieffer, J. Aaronson, N. K., & Husson, O. (2016). Reference data of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-CIPN20 Questionnaire in the general Dutch population. European Journal of Cancer, 69, 28–38. https://doi.org/10.1016/j.ejca.2016.09.020

Pachman, D. R., Qin, R., Seisler, D. K., Smith, E. M. L., Beutler, A. S., Ta, L. E., Lafky, J. M., Wagner-Johnston, N. D., Ruddy, K. J., Dakhil, S., Staff, N. P., Grothey, A., & Loprinzi, C. L. (2015). Clinical course of Oxaliplatin-induced neuropathy: Results from the Randomized Phase III Trial N08CB (Alliance). Journal of Clinical Oncology, 33(30), 3416–3422. https://doi.org/10.1200/jco.2014.58.8533

Post-White, J., Fitzgerald, M., Savik, K., Hooke, M. C., Hannahan, A. B., & Sencer, S. F. (2008). Massage therapy for children with cancer. Journal of Pediatric Oncology Nursing, 26(1), 16–28. https://doi.org/10.1177/1043454208323295

Postma, T. J., Reijneveld, J. C., & Heimans, J. J. (2013). Prevention of chemotherapy-induced peripheral neuropathy: A matter of personalized treatment? Annals of Oncology, 24(6), 1424–1426. https://doi.org/10.1093/annonc/mdt173

Seretny, M., Currie, G. L., Sena, E. S., Ramnarine, S., Grant, R., MacLeod, M. R., Colvin, L. A., & Fallon, M. (2014). Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Pain, 155(12), 2461–2470. https://doi.org/10.1016/j.pain.2014.09.020

Sharma, M., Mehrotra, S., Gray, E., Wu K, Barry, W. T., Hudis, C. A., Winer, E. P., Lyss, A. P., Toppmeyer, D., Moreno-Aspitia, A., Lad, T. E., Velasco, M., Overmoyer, B., Rugo, H. S., Ratain, M. J., & Jogarao Gobburu. (2019). Personalized management of chemotherapyâ€induced peripheral neuropathy based on a patient reported outcome: CALGB 40502 (Alliance). The Journal of Clinical Pharmacology, 60(4), 444–452. https://doi.org/10.1002/jcph.1559

Staff, N. P., Grisold, A., Grisold, W., & Windebank, A. J. (2017). Chemotherapy-induced peripheral neuropathy: A current review. Annals of Neurology, 81(6), 772–781. https://doi.org/10.1002/ana.24951

Starobova, H., & Vetter, I. (2017). Pathophysiology of chemotherapy-induced peripheral neuropathy. Frontiers in Molecular Neuroscience, 10(5). https://doi.org/10.3389/fnmol.2017.00174

Valtonen, E. J., & H.G. Lilius. (1973). Syncardial massage in diabetic and other neuropathies of lower extremities. Disease Nervous System, 34(3), 192–194.

von Hehn, C. A., Baron, R., & Woolf, C. J. (2012). Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron, 73(4), 638–652. https://doi.org/10.1016/j.neuron.2012.02.008

Wilkie, D. J., Kampbell, J., Cutshall, S., Halabisky, H., Harmon, H., Johnson, L. P., Weinacht, L., & Rake-Marona, M. (2000). Effects of massage on pain intensity, analgesics and quality of life in patients with cancer pain: A pilot study of a randomized clinical trial conducted within hospice care delivery. The Hospice Journal, 15(3), 31–53. https://doi.org/10.1080/0742-969x.2000.11882956

Woolf, C. J., & Mannion, R. J. (1999). Neuropathic pain: Aetiology, symptoms, mechanisms, and management. The Lancet, 353(9168), 1959–1964. https://doi.org/10.1016/s0140-6736(99)01307-0

Zajączkowska, R., Kocot-Kępska, M., Leppert, W., Wrzosek, A., Mika, J., & Wordliczek, J. (2019). Mechanisms of chemotherapy-induced peripheral neuropathy. International Journal of Molecular Sciences, 20(6), 1451. https://doi.org/10.3390/ijms20061451


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