Spot the CLOT: Treatment considerations for CAT

Laurie A. Sardo, Julia A. Bayadinova, Susan Jenkins


This is the fourth and final article in the Spot the CLOT series. To date, we have addressed the significance of venous thromboembolism (VTE) in patients with cancer, knowledge deficits about cancer-associated thrombosis (CAT) in both cancer patients and providers, and opportunity for addressing these knowledge gaps. This article will focus on a practical treatment approach, supported by a theoretical framework. In addition, we will discuss idiopathic VTE, often the first clue of a yet to be discovered cancer.

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Bayadinova, J. A., Sardo, L. A., Higgins-Nogareda, V., Scott, J., & MacKinnon, B. (2022). ‘Spot the CLOT’: What cancer patients want to know. Canadian Oncology Nursing, 32(1), 145–150.

Carrier, M., Blais, N., Crowther, M., Kavan, P., Le Gal, G., Moodley, O., Shivakumar, S., Suryanarayan, D., Tagalakis, V., Wu, C., & Lee, A. Y. Y. (2021). Treatment algorithm in cancer-associated thrombosis: Updated Canadian expert consensus. Current Oncology, 28(6), 5434–5451.

Carrier, M., Lazo-Langner, A., Shivakumar, S., Tagalakis, V., Zarychanski, R., Solymoss, S., Routhier, N., Douketis, J., Danovitch, K., Lee, A. Y., Le Gal, G., Wells, P. S., Corsi, D. J., Ramsay, T., Coyle, D., Chagnon, I., Kassam, Z., Tao, H., & Rodger, M. A., for the SOME Investigators. (2015). Screening for occult cancer in unprovoked venous thromboembolism. New England Journal of Medicine, 373, 697–704.

Chaput, G., Del Giudice, M. E., & Kucharski, E. (2021).Cancer screening in Ontario. Canadian Family Physician, 67(1), 27–29.

Klok, F. A., Kooiman, J., Huisman, M. V., Konstantinides, S., & Lankeit, M. (2015). Predicting anticoagulant-related bleeding in patients with venous thromboembolism: A clinically oriented review. The European Respiratory Journal, 45(1), 201–210.

Liebman, H. A. (2014). Thrombocytopenia in cancer patients. Thrombosis Research, 133 Suppl 2, S63–S69.

Prandoni, P., Falanga, A., & Piccioli, A. (2007). Cancer, thrombosis and heparin-induced thrombocytopenia. Thrombosis Research, 120(Suppl 2), S137–S140.

Prandoni, P., Lensing, A. W., Piccioli, A., Bernardi, E., Simioni, P., Girolami, B., Marchiori, A., Sabbion, P., Prins, M. H., Noventa, F., & Girolami, A. (2002). Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis. Blood, 100(10), 3484–3488.

Rosenstock, I. M. (1974). Historical origins of the Health Belief Model. Health Education Monographs, 2(4), 328–335.

Samuelson Bannow, B. T., Lee, A., Khorana, A. A., Zwicker, J. I., Noble, S., Ay, C., & Carrier, M. (2018). Management of cancer-associated thrombosis in patients with thrombocytopenia: Guidance from the SSC of the ISTH. Journal of Thrombosis and Haemostasis, 16(6), 1246–1249.

Schulman, S., Zondag, M., Linkins, L., Pasca, S., Cheung, Y. W., de Sancho, M., Gallus, A., Lecumberri, R., Molnar, S., Ageno, W., Le Gal, G., Falanga, A., Hulegårdh, E., Ranta, S., Kamphuisen, P., Debourdeau, P., Rigamonti, V., Ortel, T. L., & Lee, A. (2015). Recurrent venous thromboembolism in anticoagulated patients with cancer: Management and short-term prognosis. Journal of Thrombosis and Haemostasis, 13(6), 1010–1018.

Shimizu, T., Bouchard, M. & Mavriplis, C. (2016).Update on age-appropriate preventative measures and screening for Canadian primary care providers. Canadian Family Physician; 62(2), 131-138.

van Es, N., Le Gal, G., Otten, H.-M., Robin, P., Piccioli, A., Lecumberri, R., Palomares, L. J., Religa, P., Rieu, V., Rondina, M. T., Beckers, M. M., Prandoni, P., Salaun, P.-Y., Di Nisio, M., Bossuyt, P.M., Buller, H. R., & Carrier, M. (2017). Screening for cancer in patients with unprovoked venous thromboembolism: Protocol for a systematic review and individual patient data meta-analysis. BMJ Open, 7, e015562.


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