Patients’ experiences with cognitive changes after chemotherapy

Margaret I. Fitch, Jessica Armstrong, Suzanne Tsang


Being diagnosed with cancer and undergoing treatment can be a daunting experience. The side effects of treatment often influence a person’s quality of life. One side effect that has been identified more recently is known as “chemobrain.” Although attempts have been made to quantify and measure cognitive changes, little attention has been paid to describing the changes from the patient’s viewpoint.

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Anderson-Hanley, C., Sherman, M.L., Riggs, R., Agocha, V.B., &

Compas, B.E. (2003). Neutropsychological effects of treatments for

adults with cancer: A meta-analysis and review of the literature.

Journal of International Neuropsychology, Soc 9, 967.

Ahles, T., Saykin, A., Charlotte, F., Cole, B., Mott, L., Skalla, K., et

al. (2002). Neuropsychologic impact of standard-dose systemic

chemotherapy in long-term survivors of breast cancer and

lymphoma. Journal of Clinical Oncology, 20(2), 485–493.

Bender, C., Paraska, K., Sereika, S., Ryan, C., & Berga, S. (2001).

Cognitive function and reproductive hormones in adjuvant therapy

for breast cancer: A critical review. Journal of Pain and

Symptom Management, 21(5), 407–424.

Brezden, C., Phillips, K., Abdolell, M., Bunston, T., & Tannock, I.

(2000). Cognitive function in breast cancer patients receiving

adjuvant chemotherapy. Journal of Clinical Oncology, 18(14),


Correa, D.D., DeAngelis, L.M., Shi, W., Thaler, H., Glass, A., &

Abrey, L.E. (2004). Cognitive function in survivors of primary

central nervous system lymphoma. Neurology, 62, 548–55.

Fitch, M.I. (2000). Supportive care for cancer patients. Hospital

Quarterly, 3(4), 39–46.

Harden, J.F., Schafenacker, A., Northouse, L., Mood, D., Smith, D.,

Pienta, K., et al. (2002). Couples’ experiences with prostate cancer:

Focus group research. Oncology Nursing Forum, 29(4), 701–709.

Jansen, C.E., Miaskowski, C., Dodd, M., & Dowling, G. (2005).

Chemotherapy-induced cognitive impairment in women with

breast cancer: A critique of the literature. Oncology Nursing

Forum, 5(32), 329–342.

Johnson, C. (2006, January 20). Fatigue causes “chemo-brain” in

women. Medical Post, Toronto, 42, Issue 1, p. 15.

Minisini, A., Atalay, G., Bottomley, A., Puglisi, F., Piccarte, M., &

Biganzoli, L. (2004). What is the effect of systemic anticancer

treatment on cognitive function. Lancet Oncology, 5, 273.

Raffa, R.B., Duong, D.V., Finney, J., Garber, D.A., Lam, L.M.

Matthew, S.S., et al. (2006). Is “chemo-fog”/”chemo-brain”

caused by cancer chemotherapy? Journal of Clinical Pharmacy

& Therapeutics 31, 129–138.

Schagen, S., van Dam, F., Muller, M., Boogerd, W., Lindeboom, J.,

& Bruning, P. (1999). Cognitive deficits after postoperative

adjuvant chemotherapy for breast carcinoma. Cancer, 85(3),


Schilling, Z., Jenkins, V., & Trapala, I.S. (2006). The

(mis)classification of chemo-fog—Methodological inconsistencies

in the investigation of cognitive impairment after chemotherapy.

Breast Cancer Research & Treatment, 95, 125–129.

Speziale, H.S., & Carpenter, D.R. (1999). Qualitative Research in

Nursing: Advancing the Humanistic Imperative. Philadelphia:


Tannock, I.F., Ahles, T.A., Ganz, P.A., & van Dam, F.S. (2004).

Cognitive impairment associated with chemotherapy for cancer:

Report of a workshop. Journal of Clinical Oncology, 22, 2233.

Tchen, N., Juffs, H., Downie, F., Yi, Q., Hu, H., Chemerynsky, I., et

al. (2003). Cognitive function, fatigue, and menopausal symptoms

in women receiving adjuvant chemotherapy for breast cancer.

Journal of Clinical Oncology, 21(22), 4175–4183.

van Dam, F., Schagen, S., Muller, M., Boogerd, W., Wall, E.,

Droogleever Fortuyn, M., et al. (1998). Impairment of cognitive

function in women receiving adjuvant treatment for high-risk

breast cancer: High dose versus standard dose chemotherapy.

Journal of the National Cancer Institute, 90(3), 210–218.

Wefel, J., Lenzi, R., Theriault, R., Buzdar, A., Cruickshank, S., &

Meyers, C. (2004). Chemobrain in breast carcinoma? A prologue.

Cancer, 101(3), 466–475.

Wieneke, M., & Dienst, E. (1995). Neuropsychological assessment of

cognitive functioning following chemotherapy for breast cancer.

Psycho-Oncology, 4, 61–66.


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